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| + | Marketing for any business is important, and, of most of the kinds of marketing available including Internet marketing, direct marketing and advertising, an effective public relations strategy remains the sole type of marketing that can reach a marketplace and offer validation and credibility. Think about it, if you were to read an ad for a small business in a magazine, or read an article about that same business where the operator was showcased discussing his or her product or service and being presented as an expert, which will grab your attention? My bet is the articleIn the Internet earth, the ways you can utilize PR have altered, but the fundamentals of a powerful public-relations strategy remains the same. It all boils down for your stories. Effective PR is all about story telling. Just how can your company reflect your uniqueness? By establishing who you are with what you do. To achieve this, you need to discover how to capitalize on your unique abilities to help make your business grow and differentiate it from your own competitors.Never before have people had the oppertunity to share information on such a global scale and with such dizzying speed. Alongside papers, publications, radio, TELEVISION and the Internet, more and more paths of communication are getting to be available. In many ways, marketing is magic-it is modern day alchemy.View your organization as a full time income, breathing being. You gave life to it and it requires structure and guidance. Decide where you want the business to go. Start defining your company, your picture and your message. Now, what about taking your communication to hundreds, thousands, possibly numerous clients and/or customers? How? Two words: public relations. This is something you can try by yourself, but you can seek out the professionals for support if you can manage it. They understand the business, have the contacts and in the future, can help you save time and money. Our PR organization has represented hundreds of smaller businesses and has placed clients in a broad variety of regional and national media outlets including USA Today, Time, Oprah, the Today Show, People, the Wall Street Journal and hundreds of different media outlets. Each firm we've worked with has had a distinctive story. Your task is to find yours.Through public relations, small enterprises can compete with the big boys. It's possible to do an interview in the day and have a story saturate the country by lunchtime. Effective press placement and public-relations can legitimize, confirm, sell goods, bring in clients, forge new alliances, bring you in contact with benefactors you never realized existed, and take you to the workplaces, boardrooms and even bedrooms of the most powerful people in the world.Whether you operate an established business, are starting a new venture, or function as a consultant, an effective PR plan can help develop your business or company. So, take a moment to define your organization and your message. Build your stories; discover what's newsworthy about your business. Today launch a PR plan, simply take your stories to the media and get ready for success.Copyright |
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| − | Exp Mol Pathol. 1986 Apr;44(2):197-206.
| + | |
| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
| + | |
| − | Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A, Floridi A.
| + | |
| − | Abstract
| + | |
| − | The ability of lonidamine [1-(2,4)-dichlorobenzyl-1H-indazol-3-carboxylic acid], to induce a stress response in human and murine cultured melanoma cells has been demonstrated. In the M14 and M10 human melanoma cell lines, lonidamine enhances the synthesis of a unique set of proteins, characterized by SDS-PAGE by an Mr of about 72 kDa. In the B16 murine melanoma cell line, exposure to lonidamine increases the synthetic rate of two polypeptides of mol mass 86 and 72 kDa, respectively. Lonidamine is a drug which specifically acts on mitochondria. Therefore the observation that it can also promote a stress response indicates that the mitochondria might be one of the primary cellular targets and postulates a causal relationship between an impairment of the energy supply and induction of stress protein synthesis.
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| − | PMID: 3699138 [PubMed - indexed for MEDLINE]
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| − | Energy Metabolism/drug effects
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| − | Heat-Shock Proteins/biosynthesis*
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| − | Effect of lonidamine on protein synthesis in neoplastic cells.
| + | |
| − | [Exp Mol Pathol. 1985]
| + | |
| − | Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
| + | |
| − | [Cancer Res. 1981]
| + | |
| − | Morphological effects of lonidamine on two human-tumor cell culture lines.
| + | |
| − | [Scanning Microsc. 1989]
| + | |
| − | Review Modulation of glycolysis in neuroepithelial tumors.
| + | |
| − | [J Neurosurg Sci. 1989]
| + | |
| − | Review Lonidamine, a new approach to cancer therapy.
| + | |
| − | [Oncology. 1984]
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| − | See reviews...
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| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
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| + | |
| − | Exp Mol Pathol. 1986 Apr;44(2):197-206.
| + | |
| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
| + | |
| − | Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A, Floridi A.
| + | |
| − | Abstract
| + | |
| − | The ability of lonidamine [1-(2,4)-dichlorobenzyl-1H-indazol-3-carboxylic acid], to induce a stress response in human and murine cultured melanoma cells has been demonstrated. In the M14 and M10 human melanoma cell lines, lonidamine enhances the synthesis of a unique set of proteins, characterized by SDS-PAGE by an Mr of about 72 kDa. In the B16 murine melanoma cell line, exposure to lonidamine increases the synthetic rate of two polypeptides of mol mass 86 and 72 kDa, respectively. Lonidamine is a drug which specifically acts on mitochondria. Therefore the observation that it can also promote a stress response indicates that the mitochondria might be one of the primary cellular targets and postulates a causal relationship between an impairment of the energy supply and induction of stress protein synthesis.
| + | |
| − | PMID: 3699138 [PubMed - indexed for MEDLINE]
| + | |
| − | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
| + | |
| − | Publication Types, MeSH Terms, Substances
| + | |
| − | Publication Types
| + | |
| − | Research Support, Non-U.S. Gov't
| + | |
| − | MeSH Terms
| + | |
| − | Animals
| + | |
| − | Cell Line
| + | |
| − | Electrophoresis, Polyacrylamide Gel
| + | |
| − | Energy Metabolism/drug effects
| + | |
| − | Heat-Shock Proteins/biosynthesis*
| + | |
| − | Humans
| + | |
| − | Indazoles/pharmacology*
| + | |
| − | Melanoma/metabolism*
| + | |
| − | Mice
| + | |
| − | Mitochondria/drug effects
| + | |
| − | Neoplasm Proteins/biosynthesis
| + | |
| − | Pyrazoles/pharmacology*
| + | |
| − | Substances
| + | |
| − | Heat-Shock Proteins
| + | |
| − | Indazoles
| + | |
| − | Neoplasm Proteins
| + | |
| − | Pyrazoles
| + | |
| − | lonidamine
| + | |
| − | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
| + | |
| − | LinkOut - more resources
| + | |
| − | Supplemental Content
| + | |
| − | | + | |
| − | Save items
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| − | The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
| + | |
| − | View more options
| + | |
| − | Related citations in PubMed
| + | |
| − | Effect of lonidamine on protein synthesis in neoplastic cells.
| + | |
| − | [Exp Mol Pathol. 1985]
| + | |
| − | Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
| + | |
| − | [Cancer Res. 1981]
| + | |
| − | Morphological effects of lonidamine on two human-tumor cell culture lines.
| + | |
| − | [Scanning Microsc. 1989]
| + | |
| − | Review Modulation of glycolysis in neuroepithelial tumors.
| + | |
| − | [J Neurosurg Sci. 1989]
| + | |
| − | Review Lonidamine, a new approach to cancer therapy.
| + | |
| − | [Oncology. 1984]
| + | |
| − | See reviews...
| + | |
| − | See all...
| + | |
| − | Related information
| + | |
| − | Related Citations
| + | |
| − | Compound (MeSH Keyword)
| + | |
| − | Substance (MeSH Keyword)
| + | |
| − | Recent activity
| + | |
| − | Clear Turn Off
| + | |
| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
| + | |
| − | PubMed
| + | |
| − | See more...
| + | |
| − | You are here: NCBI > Literature > PubMedWrite to the Help Desk
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| − | BLAST
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| − | PubMed Central
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Marketing for any business is important, and, of most of the kinds of marketing available including Internet marketing, direct marketing and advertising, an effective public relations strategy remains the sole type of marketing that can reach a marketplace and offer validation and credibility. Think about it, if you were to read an ad for a small business in a magazine, or read an article about that same business where the operator was showcased discussing his or her product or service and being presented as an expert, which will grab your attention? My bet is the articleIn the Internet earth, the ways you can utilize PR have altered, but the fundamentals of a powerful public-relations strategy remains the same. It all boils down for your stories. Effective PR is all about story telling. Just how can your company reflect your uniqueness? By establishing who you are with what you do. To achieve this, you need to discover how to capitalize on your unique abilities to help make your business grow and differentiate it from your own competitors.Never before have people had the oppertunity to share information on such a global scale and with such dizzying speed. Alongside papers, publications, radio, TELEVISION and the Internet, more and more paths of communication are getting to be available. In many ways, marketing is magic-it is modern day alchemy.View your organization as a full time income, breathing being. You gave life to it and it requires structure and guidance. Decide where you want the business to go. Start defining your company, your picture and your message. Now, what about taking your communication to hundreds, thousands, possibly numerous clients and/or customers? How? Two words: public relations. This is something you can try by yourself, but you can seek out the professionals for support if you can manage it. They understand the business, have the contacts and in the future, can help you save time and money. Our PR organization has represented hundreds of smaller businesses and has placed clients in a broad variety of regional and national media outlets including USA Today, Time, Oprah, the Today Show, People, the Wall Street Journal and hundreds of different media outlets. Each firm we've worked with has had a distinctive story. Your task is to find yours.Through public relations, small enterprises can compete with the big boys. It's possible to do an interview in the day and have a story saturate the country by lunchtime. Effective press placement and public-relations can legitimize, confirm, sell goods, bring in clients, forge new alliances, bring you in contact with benefactors you never realized existed, and take you to the workplaces, boardrooms and even bedrooms of the most powerful people in the world.Whether you operate an established business, are starting a new venture, or function as a consultant, an effective PR plan can help develop your business or company. So, take a moment to define your organization and your message. Build your stories; discover what's newsworthy about your business. Today launch a PR plan, simply take your stories to the media and get ready for success.Copyright
