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The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search termSearch database The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch AdvancedHelp Result Filters The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to: Exp Mol Pathol. 1986 Apr;44(2):197-206. Induction of stress proteins by lonidamine in human and murine melanoma cells. Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A, Floridi A. Abstract The ability of lonidamine [1-(2,4)-dichlorobenzyl-1H-indazol-3-carboxylic acid], to induce a stress response in human and murine cultured melanoma cells has been demonstrated. In the M14 and M10 human melanoma cell lines, lonidamine enhances the synthesis of a unique set of proteins, characterized by SDS-PAGE by an Mr of about 72 kDa. In the B16 murine melanoma cell line, exposure to lonidamine increases the synthetic rate of two polypeptides of mol mass 86 and 72 kDa, respectively. Lonidamine is a drug which specifically acts on mitochondria. Therefore the observation that it can also promote a stress response indicates that the mitochondria might be one of the primary cellular targets and postulates a causal relationship between an impairment of the energy supply and induction of stress protein synthesis. PMID: 3699138 [PubMed - indexed for MEDLINE] The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control Publication Types, MeSH Terms, Substances Publication Types Research Support, Non-U.S. Gov't MeSH Terms Animals Cell Line Electrophoresis, Polyacrylamide Gel Energy Metabolism/drug effects Heat-Shock Proteins/biosynthesis* Humans Indazoles/pharmacology* Melanoma/metabolism* Mice Mitochondria/drug effects Neoplasm Proteins/biosynthesis Pyrazoles/pharmacology* Substances Heat-Shock Proteins Indazoles Neoplasm Proteins Pyrazoles lonidamine The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control LinkOut - more resources Supplemental Content

Save items The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites View more options Related citations in PubMed Effect of lonidamine on protein synthesis in neoplastic cells. [Exp Mol Pathol. 1985] Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. [Cancer Res. 1981] Morphological effects of lonidamine on two human-tumor cell culture lines. [Scanning Microsc. 1989] Review Modulation of glycolysis in neuroepithelial tumors. [J Neurosurg Sci. 1989] Review Lonidamine, a new approach to cancer therapy. [Oncology. 1984] See reviews... See all... Related information Related Citations Compound (MeSH Keyword) Substance (MeSH Keyword) Recent activity Clear Turn Off Induction of stress proteins by lonidamine in human and murine melanoma cells. PubMed See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI Directory GETTING STARTED NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials RESOURCES Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation POPULAR PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure FEATURED Genetic Testing Registry PubMed Health GenBank Reference Sequences Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI INFORMATION About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search termSearch database The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch AdvancedHelp Result Filters The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to: Exp Mol Pathol. 1986 Apr;44(2):197-206. Induction of stress proteins by lonidamine in human and murine melanoma cells. Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A, Floridi A. Abstract The ability of lonidamine [1-(2,4)-dichlorobenzyl-1H-indazol-3-carboxylic acid], to induce a stress response in human and murine cultured melanoma cells has been demonstrated. In the M14 and M10 human melanoma cell lines, lonidamine enhances the synthesis of a unique set of proteins, characterized by SDS-PAGE by an Mr of about 72 kDa. In the B16 murine melanoma cell line, exposure to lonidamine increases the synthetic rate of two polypeptides of mol mass 86 and 72 kDa, respectively. Lonidamine is a drug which specifically acts on mitochondria. Therefore the observation that it can also promote a stress response indicates that the mitochondria might be one of the primary cellular targets and postulates a causal relationship between an impairment of the energy supply and induction of stress protein synthesis. PMID: 3699138 [PubMed - indexed for MEDLINE] The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control Publication Types, MeSH Terms, Substances Publication Types Research Support, Non-U.S. Gov't MeSH Terms Animals Cell Line Electrophoresis, Polyacrylamide Gel Energy Metabolism/drug effects Heat-Shock Proteins/biosynthesis* Humans Indazoles/pharmacology* Melanoma/metabolism* Mice Mitochondria/drug effects Neoplasm Proteins/biosynthesis Pyrazoles/pharmacology* Substances Heat-Shock Proteins Indazoles Neoplasm Proteins Pyrazoles lonidamine The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control LinkOut - more resources Supplemental Content

Save items The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites View more options Related citations in PubMed Effect of lonidamine on protein synthesis in neoplastic cells. [Exp Mol Pathol. 1985] Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. [Cancer Res. 1981] Morphological effects of lonidamine on two human-tumor cell culture lines. [Scanning Microsc. 1989] Review Modulation of glycolysis in neuroepithelial tumors. [J Neurosurg Sci. 1989] Review Lonidamine, a new approach to cancer therapy. [Oncology. 1984] See reviews... See all... Related information Related Citations Compound (MeSH Keyword) Substance (MeSH Keyword) Recent activity Clear Turn Off Induction of stress proteins by lonidamine in human and murine melanoma cells. PubMed See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI Directory GETTING STARTED NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials RESOURCES Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation POPULAR PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure FEATURED Genetic Testing Registry PubMed Health GenBank Reference Sequences Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI INFORMATION About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA