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| − | The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to:
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| − | Radiother Oncol. 1986 Apr;5(4):303-10.
| + | Não foi encontrado nenhum resultado contendo todos os seus termos de pesquisa. |
| − | Predictive assays for the therapy of rectum carcinoma.
| + | |
| − | Streffer C, van Beuningen D, Gross E, Schabronath J, Eigler FW, Rebmann A.
| + | Sua pesquisa - abou3726202 - não encontrou nenhum documento correspondente. |
| − | Abstract
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| − | Cytofluorometric DNA measurements showed that about 55% of rectum carcinoma (129 patients) had tumours with an abnormal DNA content (DNA aneuploidy). For patients with such a tumour the prognosis was worse than for patients with DNA diploid tumours. From the DNA histograms the number of S-phase cells was calculated. In tumours with the stage pT3, which disseminated to lymph nodes or metastasized, a higher number of S-phase cells was found than in tumours with the staging pT3N0M0. In all untreated tumours cells with micronuclei were found. This demonstrated cell loss. In most tumours this effect was considerable. The ratio:number of S-phase cells/number of cells with micronuclei may allow a rough estimate for cell turnover. In patients with a bad prognosis and in those patients who had a local recurrence after resection of the tumour this ratio was high. In 34 patients the parameters were measured before and after preoperative radiotherapy. In some tumours a rapid increase of S-phase cells occurred after irradiation, this effect might express repopulation. In these patients a local recurrence was frequently found. From the data obtained so far a prediction for local recurrences might be possible from the determination of nuclear protein bound SH-groups. The determination of micronuclei indicated that it can be used as a measure for radiation response in tumours. All parameters show a high variability between individual tumours. A further study is useful whether the measured parameters are suitable as predictors.
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| − | PMID: 3726167 [PubMed - indexed for MEDLINE]
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| − | Related citations in PubMed
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| − | DNA measurements and micronuclei in human rectal carcinoma.
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| − | [Radiat Med. 1985]
| + | |
| − | An approach to the individualization of cancer therapy--determination of DNA, SH-groups and micronuclei.
| + | |
| − | [Strahlentherapie. 1984]
| + | |
| − | Carcinoma of the rectum. Possible cellular predictors of metastatic potential and response to radiation therapy.
| + | |
| − | [Dis Colon Rectum. 1996]
| + | |
| − | Review [Value of local surgical therapy for rectal cancer. A literature analysis].
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| − | [Zentralbl Chir. 2003]
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| − | Review The clinical significance of the circumferential resection margin following preoperative pelvic chemo-radiotherapy in rectal cancer: why we need a common language.
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| − | [Colorectal Dis. 2006]
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| − | See reviews...
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| − | Cited by 1 PubMed Central article
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| − | Micronucleus formation in human tumour cells: lack of correlation with radiosensitivity.
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| − | [Br J Cancer. 1993]
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| + | |
| − | Radiother Oncol. 1986 Apr;5(4):303-10.
| + | |
| − | Predictive assays for the therapy of rectum carcinoma.
| + | |
| − | Streffer C, van Beuningen D, Gross E, Schabronath J, Eigler FW, Rebmann A.
| + | |
| − | Abstract
| + | |
| − | Cytofluorometric DNA measurements showed that about 55% of rectum carcinoma (129 patients) had tumours with an abnormal DNA content (DNA aneuploidy). For patients with such a tumour the prognosis was worse than for patients with DNA diploid tumours. From the DNA histograms the number of S-phase cells was calculated. In tumours with the stage pT3, which disseminated to lymph nodes or metastasized, a higher number of S-phase cells was found than in tumours with the staging pT3N0M0. In all untreated tumours cells with micronuclei were found. This demonstrated cell loss. In most tumours this effect was considerable. The ratio:number of S-phase cells/number of cells with micronuclei may allow a rough estimate for cell turnover. In patients with a bad prognosis and in those patients who had a local recurrence after resection of the tumour this ratio was high. In 34 patients the parameters were measured before and after preoperative radiotherapy. In some tumours a rapid increase of S-phase cells occurred after irradiation, this effect might express repopulation. In these patients a local recurrence was frequently found. From the data obtained so far a prediction for local recurrences might be possible from the determination of nuclear protein bound SH-groups. The determination of micronuclei indicated that it can be used as a measure for radiation response in tumours. All parameters show a high variability between individual tumours. A further study is useful whether the measured parameters are suitable as predictors.
| + | |
| − | PMID: 3726167 [PubMed - indexed for MEDLINE]
| + | |
| − | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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| − | Publication Types, MeSH Terms, Substances
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| − | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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| − | The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
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| − | View more options
| + | |
| − | Related citations in PubMed
| + | |
| − | DNA measurements and micronuclei in human rectal carcinoma.
| + | |
| − | [Radiat Med. 1985]
| + | |
| − | An approach to the individualization of cancer therapy--determination of DNA, SH-groups and micronuclei.
| + | |
| − | [Strahlentherapie. 1984]
| + | |
| − | Carcinoma of the rectum. Possible cellular predictors of metastatic potential and response to radiation therapy.
| + | |
| − | [Dis Colon Rectum. 1996]
| + | |
| − | Review [Value of local surgical therapy for rectal cancer. A literature analysis].
| + | |
| − | [Zentralbl Chir. 2003]
| + | |
| − | Review The clinical significance of the circumferential resection margin following preoperative pelvic chemo-radiotherapy in rectal cancer: why we need a common language.
| + | |
| − | [Colorectal Dis. 2006]
| + | |
| − | See reviews...
| + | |
| − | See all...
| + | |
| − | Cited by 1 PubMed Central article
| + | |
| − | Micronucleus formation in human tumour cells: lack of correlation with radiosensitivity.
| + | |
| − | [Br J Cancer. 1993]
| + | |
| − | Related information
| + | |
| − | Related Citations
| + | |
| − | Cited in PMC
| + | |
| − | Recent activity
| + | |
| − | Clear Turn Off
| + | |
| − | Predictive assays for the therapy of rectum carcinoma.
| + | |
| − | PubMed
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| − | See more...
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| − | You are here: NCBI > Literature > PubMedWrite to the Help Desk
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| − | PubMed Central
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| − | OMIM
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Você quis dizer: abou 3726202
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