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| − | Exp Mol Pathol. 1986 Apr;44(2):197-206.
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| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
| + | |
| − | Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A, Floridi A.
| + | |
| − | Abstract
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| − | The ability of lonidamine [1-(2,4)-dichlorobenzyl-1H-indazol-3-carboxylic acid], to induce a stress response in human and murine cultured melanoma cells has been demonstrated. In the M14 and M10 human melanoma cell lines, lonidamine enhances the synthesis of a unique set of proteins, characterized by SDS-PAGE by an Mr of about 72 kDa. In the B16 murine melanoma cell line, exposure to lonidamine increases the synthetic rate of two polypeptides of mol mass 86 and 72 kDa, respectively. Lonidamine is a drug which specifically acts on mitochondria. Therefore the observation that it can also promote a stress response indicates that the mitochondria might be one of the primary cellular targets and postulates a causal relationship between an impairment of the energy supply and induction of stress protein synthesis.
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| − | PMID: 3699138 [PubMed - indexed for MEDLINE]
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| − | Energy Metabolism/drug effects
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| − | Heat-Shock Proteins/biosynthesis*
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| − | Humans
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| − | Effect of lonidamine on protein synthesis in neoplastic cells.
| |
| − | [Exp Mol Pathol. 1985]
| |
| − | Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
| |
| − | [Cancer Res. 1981]
| |
| − | Morphological effects of lonidamine on two human-tumor cell culture lines.
| |
| − | [Scanning Microsc. 1989]
| |
| − | Review Modulation of glycolysis in neuroepithelial tumors.
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| − | [J Neurosurg Sci. 1989]
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| − | Review Lonidamine, a new approach to cancer therapy.
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| − | [Oncology. 1984]
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| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
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| − | The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to:
| |
| − | Exp Mol Pathol. 1986 Apr;44(2):197-206.
| |
| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
| |
| − | Delpino A, Nista A, Marcante ML, Ferrini U, Silvestrini B, Caputo A, Floridi A.
| |
| − | Abstract
| |
| − | The ability of lonidamine [1-(2,4)-dichlorobenzyl-1H-indazol-3-carboxylic acid], to induce a stress response in human and murine cultured melanoma cells has been demonstrated. In the M14 and M10 human melanoma cell lines, lonidamine enhances the synthesis of a unique set of proteins, characterized by SDS-PAGE by an Mr of about 72 kDa. In the B16 murine melanoma cell line, exposure to lonidamine increases the synthetic rate of two polypeptides of mol mass 86 and 72 kDa, respectively. Lonidamine is a drug which specifically acts on mitochondria. Therefore the observation that it can also promote a stress response indicates that the mitochondria might be one of the primary cellular targets and postulates a causal relationship between an impairment of the energy supply and induction of stress protein synthesis.
| |
| − | PMID: 3699138 [PubMed - indexed for MEDLINE]
| |
| − | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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| − | Publication Types, MeSH Terms, Substances
| |
| − | Publication Types
| |
| − | Research Support, Non-U.S. Gov't
| |
| − | MeSH Terms
| |
| − | Animals
| |
| − | Cell Line
| |
| − | Electrophoresis, Polyacrylamide Gel
| |
| − | Energy Metabolism/drug effects
| |
| − | Heat-Shock Proteins/biosynthesis*
| |
| − | Humans
| |
| − | Indazoles/pharmacology*
| |
| − | Melanoma/metabolism*
| |
| − | Mice
| |
| − | Mitochondria/drug effects
| |
| − | Neoplasm Proteins/biosynthesis
| |
| − | Pyrazoles/pharmacology*
| |
| − | Substances
| |
| − | Heat-Shock Proteins
| |
| − | Indazoles
| |
| − | Neoplasm Proteins
| |
| − | Pyrazoles
| |
| − | lonidamine
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| − | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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| − | Effect of lonidamine on protein synthesis in neoplastic cells.
| + | |
| − | [Exp Mol Pathol. 1985]
| + | Página inicial do Imagens do Google Alterar para a versão básicaAjudaEnviar feedback |
| − | Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells.
| + | Página inicial do GoogleSoluções de publicidadePrivacidade e TermosSobre o Google Resultados da pesquisa |
| − | [Cancer Res. 1981]
| + | |
| − | Morphological effects of lonidamine on two human-tumor cell culture lines.
| + | |
| − | [Scanning Microsc. 1989]
| + | Juan Jose Martinez Villalba Slideshow & Video | TripAdvisor |
| − | Review Modulation of glycolysis in neuroepithelial tumors.
| + | tripwow.tripadvisor.com - 720 × 540 - Mais tamanhos |
| − | [J Neurosurg Sci. 1989]
| + | Visitar página Visualizar imagem original Mais informações |
| − | Review Lonidamine, a new approach to cancer therapy.
| + | As imagens podem ter direitos autorais. |
| − | [Oncology. 1984]
| + | |
| − | See reviews...
| + | Página inicial do Imagens do Google Alterar para a versão básicaAjudaEnviar feedback |
| − | See all...
| + | Página inicial do GoogleSoluções de publicidadePrivacidade e TermosSobre o Google |
| − | Related information
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| − | Related Citations
| + | |
| − | Compound (MeSH Keyword)
| + | |
| − | Substance (MeSH Keyword)
| + | |
| − | Recent activity
| + | |
| − | Clear Turn Off
| + | |
| − | Induction of stress proteins by lonidamine in human and murine melanoma cells.
| + | |
| − | PubMed
| + | |
| − | See more...
| + | |
| − | You are here: NCBI > Literature > PubMedWrite to the Help Desk
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| − | Simple NCBI Directory
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| − | GETTING STARTED
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| − | PubMed Central
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| − | Mouse Genome
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| − | Influenza Virus
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Página inicial do Imagens do Google Alterar para a versão básicaAjudaEnviar feedback
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